His public art street murals are a continuation of his heritage and connection to the Mexican Masters Diego Rivera, José Clemente Orozco, and David Siqueiros, who are referred to as "los tres grandes" (the three great ones). His work is inspired by the empowerment of marginalized communities and the fight for representation.

Marka27's artistry encompasses paintings, murals, drawings, mixed-media pieces, and private commissions for major brands. His robust palette combines elements of street and pop culture with Mexican and Indigenous aesthetics, which he has coined as his signature look, "Neo Indigenous." Marka27's work has cemented his place in graffiti and street art history, and he has flourished as a product designer, gallery artist, toy designer, and more. Marka27 has emerged as one of the most sought-after muralists in the world and has mastered his craft since before "street art" was even a term.